There are alot of unique theme based hotel inlas vegas similar to TI and Luxor. I was on a quest to find out what is the most unique hotel in Las Vegas. What I found was that the most unique hotel in terms of interesting design and layout was not even on the Las Vegas strip. For me it was the Artisan hotel that is just a few streets away from the strip. There is carved wooden sculptures on the ceiling and the place is dimly lit. What about you? What is the most unique hotel that you have visited in Las Vegas?
Treasure Island is the one I'm most aware of, I'm sure a lot of the more expensive hotels would be worth checking out as well. I heard the Venetian was quite nice, but I don't recall there being a theme for it, unless I just didn't read into it enough.